Project leaders: Marc MALEVAL , François FENAILLE
For diagnosis and therapy - (15/06/2023)
Glycomics explores the oligosaccharides present in a biological fluid as a potential new source of biomarkers for diagnosing and monitoring the development of various pathologies (cancer, Alzheimer’s disease, etc.). Nevertheless, the sample preparation materials employed at present involve several manual and time-consuming stages that hinder high-throughput analysis. LEDNA, a laboratory specialising in nanomaterials, in close collaboration with the Laboratory for Innovations in Mass Spectrometry (LI-MS), has recently patented a robust sol-gel process for the fabrication and shaping of miniaturised hierarchical porosity monoliths (HPMs). The utilization of these HPMs for sample preparation in the LI-MS laboratory facilitates an uncomplicated, efficient and prompt analysis of glycomics (18h compared to 48h), outperforming the procedures at present employed in labs. The standardization of manufacturing methods for devices containing HPMs in kit form and associated protocols will allow their use in a hospital context and significantly improve clinical and research work in the promising field of glycomics, with a potential impact on precision medicine.
Contact : Marc MALEVAL (CEA – IRAMIS/NIMBE/LEDNA – UMR 3685) et François FENAILLE (CEA – DMTS/SPI/LI-MS LI-MS)
